New races and different ideas aside, one key factor for Domenicali in F1's upward trajectory is that Lewis Hamilton signs a new deal with Mercedes.
While F1 could naturally survive without Hamilton, as it has done throughout many eras in the past when stars have departed, as a global ambassador for the sport and the spotlight he shines upon it, Domenicali knows the seven-time champion is a powerful marketing tool.
"Lewis is an incredible driver, an incredible man, an incredible athlete, and he has given to Formula 1 a different dimension that is over the sport, I would say," assessed Domenicali.
"Lewis is a massive ambassador for Formula 1, who is really very important for Formula 1 because he is the one who is embracing other values into the discussion, with his face [now recognised] in a lot of areas away from the sport."
Even to Domenicali, it seems inconceivable Hamilton will not put pen to paper, not with history beckoning as F1's first eight-time champion after equalling the record of Michael Schumacher last season.
"As soon as we know what his future will be, it will be great to see him fighting for something that no-one would have thought possible to achieve after Michael's era," enthused Domenicali. "It will be really great."
When he talks, and no matter the subject, you can sense Domenicali is bristling with enthusiasm that can only serve F1 well over the coming years.
Images courtesy of Motorsport Images.